Precision Medicine applications for neurological disorders (neurodevelopmental and neurodegenerative) based on big data acquisition and analysis (genetic, physiological) using human induced Pluripotent Stem Cell-derived models 


Εφαρμογές Ιατρικής Ακριβείας για νευρολογικές διαταραχές (νευροαναπτυξιακές και νευροεκφυλιστικές) με απόκτηση και ανάλυση μαζικών-μεγάλων δεδομένων (γενετικών, φυσιολογικών) χρησιμοποιώντας μοντέλα από επαγόμενα Πολυδύναμα Βλαστικά Κύτταρα.

Effective treatment of neurological disorders (neurodevelopmental or neuropsychiatric) relies on reliable biomarker discovery and generation of personalized therapies and is limited by the fact that patient brain tissue cannot be accessed due to ethical limitations. Induced Pluripotent Stem Cells (iPSC) derived from patient somatic cells (e.g. skin or blood) can be used to generate models of human brain cells (2D or 3D) and recapitulate key genetic and physiological properties of the human brain in health and disease. The BRI high-throughput platform can perform acquisition and analysis of genetic (genome-wide) and physiological (electrophysiology) big data. The objective is to use this iPSC-based platform to design, validate and deploy tools, services, and products for the following categories: 1) biomarker discovery, 2) drug discovery/screening, 3) diagnostics, 4) toxicology, 5) pharmacokinetics/pharmacodynamics, 6) big data analysis (bioinformatics).

BRI Lab (ΙΩΑΝΝΙΝΑ) - Neurobiology
Υπέυθυνος Επικοινωνίας: Χρήστος Γκόγκας
Email: cgkogkas@bri.forth.gr