The Athena Research and Innovation Center in Information, Communication and Knowledge Technologies (Athena RC) was founded in 2003 in three cities, Athens, Patras and Xanthi. It is the only research center in Greece that is exclusively focused on Digital Sciences and Technologies. Its structure includes three Institutes, on Language and Speech Processing, Industrial Systems, and Information Management Systems, respectively, and eight Units, on Technology Clusters, Space Programs, Robot Perception and Interaction, Environmental and Networking Technologies and Applications, Pharma-Informatics, Sustainable Development, Artificial Intelligence-Data Science-Algorithms, and Women’s Innovation and Entrepreneurship, respectively. The vision of Athena RC is to conduct outstanding research in Information and Communication Technologies, pursuing solutions to global challenges, addressing local needs, and producing novel and deep technological results with a broad impact on other sciences, industry, and society at large. In addition to research on core problems in digital technologies, interdisciplinarity is a fundamental characteristic of the activities of Athena RC, with particular emphasis (but no limitation) on computational elements of the fields of precision agriculture, agri-food, precision medicine, biology, biodiversity, earth observation, space science, engineering, mechanics, linguistics, archaeology, and the arts. Next to its research portfolio, Athena RC is also very strong in innovation and entrepreneurial activities, including the co-foundation of several successful spin-off companies.